Haploidentical Stem Cell Transplantation for Children With Acquired Severe Aplastic Anemia
Status:
Unknown status
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Rationale: Fludarabine, cyclophosphamide, anti-thymocyte globulin and low-dose total body
irradiation (LD-TBI) may induce the engraftment cross the immunologic barrier in the setting
of HLA-haploidentical allogeneic hematopoietic cell transplantation. In addition, depletion
of CD3 cells may contribute to prevent developing severe acute graft versus host disease
(GVHD) in haploidentical transplantation.
Purpose: Phase II trials to evaluate the efficacy of haploidentical stem cell transplantation
with fixed dose of T cells after in vitro T cell depletion using CD3 monoclonal antibody for
children with acquired severe aplastic anemia