Harefield Recovery Protocol Study for Patients With Refractory Chronic Heart Failure
Status:
Terminated
Trial end date:
2010-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate whether patients with chronic heart failure not due
to coronary artery disease who require use of a left ventricular assist device (LVAD) for
refractory heart failure can recover sufficient heart function to allow the pump to be
explanted. The study aims to avoid the need for transplantation in these patients by using
standard heart failure medications to reduce the size of the left ventricle and then using
the investigational drug, clenbuterol, to further improve left ventricular function.
Phase:
Phase 1
Details
Lead Sponsor:
Francis D. Pagani
Collaborators:
Georgetown University Montefiore Medical Center Northwestern University Ohio State University Texas Heart Institute Thoratec Corporation University of Minnesota University of Minnesota - Clinical and Translational Science Institute University of Pennsylvania