To determine by sequential coronary arteriography whether a lipid-lowering diet with and
without lipid-lowering drugs could reverse coronary artery disease in normocholesterolemic
patients. Also, to test whether fish oil supplements could improve human coronary
atherosclerosis. Finally, to determine the effect of combination therapy with lipid-reducing
drugs in patients with coronary heart disease and "normal" cholesterol levels. At least three
clinical trials were conducted.