Hashimoto - a Surgical Disease. Absolute Total Thyroidectomy Makes Antibodies Disappear and Ameliorates Symptoms

• Status: Unknown status
• Trial end date: 0000-00-00
• Target enrollment: 150
• Participant gender: Both

Summary

The investigators have already proven that absolute total thyroidectomy gives elimination of anti-TPO antibodies. Our hypothesis is that this elimination also eliminates the typical Hashimoto symptoms, namely: Serious tiredness, increased need of sleep, pain in musculature and joints and dryness in eyes and mouth. The prerequisite for this effect is the absolute total thyroidectomy. There exists no other treatment that can eliminate the antibodies. The study is randomized between operation and ordinary conservative medical treatment with thyroxine control and supplementation. The symptoms in both groups are evaluated by 5 different Quality of Life schemes, internationally approved.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sykehuset Telemark
• Collaborator: Haukeland University Hospital
• Treatments: Antibodies; Hormones
• Last Updated: 2014-12-17

Criteria

Inclusion Criteria:

1. Patients referred due to typical symptoms, believed to be related to Hashimoto´s disease, but not relieved by thyroxin substitution. Optimal thyroid substitution treatment is already provided.

2. Anti-TPO>1000

3. Hypothyroidism with a need for thyroxin supplementation

4. Written informed consent by the patient - information particularly emphasising and quantifying the risk of complications (e.g. recurrent laryngeal nerve palsy). The patient should be informed by a medical endocrinologist as well as a surgeon.

Exclusion Criteria:

1. Patients <18 years of age.

2. Pregnancy.

3. Unable to comprehend information adequately to give informed consent.

4. General anaesthesiological contraindications.

5. An unexpected finding of cancer in the surgical group is not a reason for exclusion per se, but this group should be analyzed separately. It is expected that any different loading in Quality of life would bias the medically treated group.