Heart Rate Response to Atropine Doses Less Than 0.1mg IV to Anesthetized Infants

• Status: Completed
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: All

Summary

An infants heart rate is very important because it ensures that blood is pumped to all organs in the body. Heart rate may decrease during anesthesia and surgery, and this is why the anesthesiologist will often give a medication to prevent this from happening. The most common drug for this purpose is called atropine. The dose of most drugs given to babies is based upon the baby's weight, but some believe that the dose of atropine should not be less than 0.1mg. However there is no evidence to support this minimum dose. A larger dose of atropine may cause a very fast heart rate instead. Anesthesiologists routinely dose the atropine based upon the baby's weight without regard for a minimum dose.

The purpose of the present study is to measure the heart rate after doses of atropine in neonates and infants who receive less than 0.1 mg.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: State University of New York at Buffalo
• Treatments: Atropine

Criteria

Inclusion Criteria:

1. Age : 0-2 years old

2. Weight : less than the 95th percentile for age and height ( no more than 15kg )

3. ASA classification : I-II

4. Meets the hospital and department of anesthesiology guidelines with respect to peri-operative care

Exclusion Criteria:

1. History of heart disease

2. Any condition predisposing to arrhythmia

3. Any medication known to influence the heart rate

4. Child taking anti-cholinergic medication routinely

5. The use of succinylcholine anticipated (will cause bradycardia)

6. Rapid sequence intubation is required (due to aspiration risk)

7. Known difficult airway (may be difficult to bag mask ventilate)