Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol

• Status: Completed
• Trial end date: 2009-09-30
• Target enrollment: 0
• Participant gender: All

Summary

Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.

Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).

Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yaounde Central Hospital
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• consenting patients referred to or diagnosed at the National Centre of Obesity of the Yaounde Central Hospital as having hyperthyroidism

• naïve of all treatment specific for hyperthyroidism.

• aged 18-70 years

Exclusion Criteria:

• Patients already under a specific treatment for hyperthyroidism

• Patients taking beta blockers or any other cardiospecific treatment

• Patients presenting complications including acute thyrotoxic crisis, or symptomatic cardiac failure

• Contraindications to the prescription of beta blockers