Heart and Blood Pressure Study: The Effect of Aortic Impedance on Myocardial Relaxation

• Status: Completed
• Trial end date: 2006-12-20
• Target enrollment: 0
• Participant gender: All

Summary

Does dilation of blood vessels (vasodilation), which decreases aortic stiffness, have a greater effect on heart myocardium relaxation (diastole) than vasodilation which affects mean pressure equally without improving aortic stiffness?

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Wisconsin, Madison
• Collaborator: Scios, Inc.
• Treatments: Hydralazine; Natriuretic Peptide, Brain

Criteria

Inclusion Criteria:

• Subjects over the age of 65

Exclusion Criteria:

• Have known or suspected coronary artery disease

• Have known or suspected left ventricular dysfunction

• Have significant valvular, infiltrative, pericardial, or congenital heart disease

• Have a resting systolic blood pressure < 100 mmHg

• Have had an adverse reaction to nesiritide or hydralazine

• Have a serum creatinine > 2 mg/dl at Visit 1