Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy
Status:
Completed
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
This study aims at evaluating efficacy and safety of berberine-containing quadruple
therapy(berberine, lansoprazole, bismuth and amoxicillin) versus clarithromycin-containing
quadruple therapy (clarithromycin,lansoprazole, bismuth and amoxicillin) in H. pylori
eradication. It is hypothesized that berberine-containing quadruple therapy is non-inferior
to clarithromycin-containing quadruple therapy. Patients with confirmed H. pylori positive
status will be randomized to one of the treatments described above. At week 2 and 6 follow-up
visits, a urea breath test(UBT) will be performed to confirm eradication.