Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: Male

Summary

to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Baqiyatallah Medical Sciences University
• Treatments: Mechlorethamine; Mustard Gas

Criteria

Inclusion Criteria:

• exposure to sulfur mustard

• worsening dyspnea during the last 10 days

• respiratory rate of >25/min

• arterial pH<7.35

• PaCO2 of >50 mmHg

• PaO2 of <50 mmHg

Exclusion Criteria:

• recent pneumothorax (<1 month)

• severe respiratory failure or hemodynamic instability with forthcoming intubation

• FIO2 of <0.4

• impaired consciousness or absence of patient cooperation

• facial lesions precluding NIPPV