Helping Olfaction and Nutrition On Renal Replacement

• Status: Recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This clinical trial examines whether nasal theophylline administration can improve olfaction and nutrition in hemodialysis patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Treatments: Theophylline

Criteria

Inclusion Criteria:

• ESRD requiring chronic outpatient hemodialysis

• Able to provide written consent

• Defects in smell identification and/or smell threshold detection as measured by "Scratch-and-sniff" University of Pennsylvania Smell Identification Test (UPSIT) and Smell Threshold Test

Exclusion Criteria:

• Prior allergic reaction to theophylline

• Patients currently treated with theophylline for clinical indication

• Pregnancy or lactation

• ESRD patients on peritoneal dialysis

• Patients hospitalized at the time of study enrollment