Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Giving chemotherapy, such as busulfan, fludarabine, and melphalan, before a donor
umbilical cord blood stem cell transplant helps stop the growth of abnormal or cancer cells
and prepares the patient's bone marrow for the stem cells. When the healthy stem cells from a
donor are infused into the patient they may help the patient's bone marrow make stem cells,
red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a
donor can make an immune response against the body's normal cells. Giving cyclosporine and
mycophenolate mofetil may stop this from happening.
PURPOSE: This phase II trial is studying how well combination chemotherapy followed by a
donor umbilical cord blood transplant works in treating infants with high-risk acute leukemia
or myelodysplastic syndromes.