Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:

• Status: Recruiting
• Trial end date: 2023-02-15
• Target enrollment: 0
• Participant gender: All

Summary

The relative increase in the mPAP with the same unit increase in MAP adjusted for baseline, and RV function assessed by GLS, between VP and NE in patients with normal and increased pulmonary artery pressure, who require vasopressor support during cardiac surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Arginine Vasopressin; Norepinephrine; Vasopressins

Criteria

Inclusion criteria:

Adults> 18 years of age

• Elective cardiac surgery with the use of CPB

• Patients with pulmonary artery catheter insertion

• Systemic hypotension (MAP < 70 mmHg) requiring continuous infusion of vasopressor

Exclusion Criteria:

• Transplant surgery

• Ventricular assist device implantation other than intra-aortic balloon counter-pulsation

• Pulmonary endarterectomy

• Thoracoabdominal aneurysm repair

• Inhalational pulmonary vasodilators (e.g. Epoprostenol) administration before insertion of pulmonary artery catheter

• Vasopressin is started as the first choice of pressor per clinical staff discretion