Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
Compression garments have been shown to be effective in the treatment of orthostatic
hypotension in autonomic failure patients. The purpose of this study is to determine the
hemodynamic mechanisms by which abdominal compression (up to 40 mm Hg) improve the standing
blood pressure and orthostatic tolerance in these patients, and to compare them with those of
the standard of care midodrine. The investigators will test the hypothesis that abdominal
compression will blunt the exaggerated fall in stroke volume and the increase in abdominal
vascular volume during head up tilt.
Phase:
Phase 1
Details
Lead Sponsor:
Vanderbilt University Vanderbilt University Medical Center