Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock
Status:
Recruiting
Trial end date:
2025-01-01
Target enrollment:
Participant gender:
Summary
Norepinephrine is a catecholamine that is the first-line vasopressor for septic shock. The
addition of non-catecholamine vasopressors, including vasopressin and angiotensin-II may be
used in adults with septic shock that have inadequate mean arterial pressure while on
norepinephrine. Uncertainty exists regarding the timing of initiation of these agents and
there is a lack of data comparing their safety and efficacy.
The current literature suggests that earlier initiation of angiotensin-II will have a more
significant reduction on norepinephrine-equivalent dose compared to later initiation. In
addition, approximately half of patients initiated on vasopressin do not have an early
hemodynamic response 6 hours after initiation. The purpose of this study is to evaluate the
efficacy of angiotensin-II when used as the second vasopressor agent for septic shock.