Hemodynamic Stability During Carotid Endarterectomy.Comparison of LENOXe™ (Xenon 100% v/v) Versus Sevoflurane

• Status: Completed
• Trial end date: 2010-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the hemodynamics effects of two usual hypnotic agents (LENOXe ™ (xenon 100 % v/v) and sevoflurane) during a general anesthesia for carotid endarterectomy in elderly patients. The hypothesis is that the use of the LENOXe ™ (xenon 100 % v/v) allows to obtain per-operating hemodynamic stability non inferior than with sevoflurane.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Air Liquide Santé International
• Collaborator: Groupe Hospitalier Pitie-Salpetriere
• Treatments: Anesthetics; Sevoflurane; Xenon

Criteria

Inclusion Criteria:

• Patients > 55 years, status ASA II

• Carotid endarterectomy elected surgery

• Signed informed consent

Exclusion Criteria:

Related to the patients:

• Histories of hypersensibility in both products used in the study

• uncontrolled arterial High Blood Pressure in the preoperative anaesthesia screening

• Severe cardiac failure (FEVG < 30 %)

• Major lung or airways disease and\or required per-operating FiO2> 35 %

• Elevated intracranial pressure

• Pregnancy, breast feeding

• Major protected, under supervision, under guardianship

• Every patient entering within the framework of the contraindications indicated to §4.3 of the summary of the characteristics of tested products (LENOXe ™ (xenon 100 % v/v), sevoflurane)

Related to the surgery:

• Controlateral carotid stenosis superior to 70 % and\or preoperative indication in the implementation per-operating of a carotid shunt

• Surgery realized within the framework of an emergency

• Combined Surgery