Hemodynamic and Electrocardiographic Effects of Hyaluronidase Associated With Local Anaesthetics
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Among the adjuvants to local anaesthetics (LA), the enzyme hyaluronidase is most often used
as a diffuser agent of the LA in ophthalmic anaesthesia. It serves to improve clinical
efficacy and prolong anaesthesia as an alternative to long-lasting and potentially more
dangerous LA, especially in patients with increased cardiovascular risk. There is scarce
clinical data about the safety of the use of hyaluronidase in dental procedures.
This study aimed to compare hemodynamic and electrocardiographic variables during a dental
surgical procedure using a local anaesthetic associated with hyaluronidase or placebo in
healthy subjects.
Phase:
Phase 4
Details
Lead Sponsor:
Mauricio Jose Tornelli
Collaborator:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Treatments:
Anesthetics Anesthetics, Local Epinephrine Epinephryl borate Mepivacaine Racepinephrine