Heparin Intraoperative Instillation for Lower Urinary Tract Symptoms After Benign Hysterectomy

• Status: Unknown status
• Trial end date: 2020-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study will explore the application of placing heparin into the bladder via a catheter to decrease postoperative lower urinary tract symptoms (LUTS) and urinary tract infection (UTI) symptoms such as urinary frequency, urinary urgency, pain with urination, or difficulty voiding following hysterectomy (surgically removing the uterus). The investigators hypothesize that heparin bladder instillations will reduce LUTS, UTI symptoms, and improve patient satisfaction following hysterectomy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Christ Hospital
• Treatments: Calcium heparin; Heparin

Criteria

Inclusion Criteria:

• 18 to 85-years old

• scheduled to undergo a benign hysterectomy

Exclusion Criteria:

• non-English speakers

• current use of anticoagulants or thrombolytic agents

• known adverse reaction or hypersensitivity to heparin

• history of or active genitourinary tract cancer (bladder, uterine, cervical, ovarian or vaginal)

• history of neurogenic bladder

• pelvic irradiation

• chemical cystitis

• pregnancy

• antibiotic use within the past 30 days

• Surgical procedures involving: anterior or posterior colporrhaphy, vaginal mesh excision, fistula repair, diverticulum repair, urethral reconstruction, planned or incidental cystotomy