Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Hepatic arterial infusion uses a catheter to deliver anticancer substances directly into the liver. Drugs used in chemotherapy, such as melphalan, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different ways may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving an hepatic arterial infusion of melphalan together with hepatic perfusion works in treating patients with unresectable liver cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Delcath Systems Inc.
• Collaborator: National Cancer Institute (NCI)
• Treatments: Melphalan

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed hepatic malignancy

• Unresectable disease

• Disease predominantly in the parenchyma of the liver

• One of the following primary tumor histologies:

• Adenocarcinoma of gastrointestinal or other origin

• Neuroendocrine tumor (except gastrinoma)

• Primary hepatic malignancy (e.g., hepatocellular cancer or intra-hepatic cholangiocarcinoma)

• Cutaneous or ocular melanoma (patients must have received prior regional melphalan therapy)

• Hepatic metastases from colorectal tumors allowed provided patient has undergone prior first-line chemotherapy, including irinotecan or oxaliplatin

• Limited unresectable extrahepatic disease on preoperative radiological studies allowed if life-limiting component of progressive disease is in the liver

• Limited extrahepatic disease includes, but is not limited to, the following:

• Up to 4 pulmonary nodules each < 1 cm in diameter

• Retroperitoneal lymph nodes each < 3 cm in diameter

• Less than 10 skin or subcutaneous metastases each < 1 cm in diameter

• Asymptomatic bone metastases that have been or could be palliatively treated with external beam radiotherapy

• Resectable solitary metastasis to any site

• Hormone receptor status:

• Not specified

PATIENT CHARACTERISTICS:

Age

• 16 and over

Sex

• Male or Female

Menopausal status

• Not specified

Performance status

• ECOG 0-2

Life expectancy

• Not specified

Hematopoietic

• Platelet count ≥ 75,000/mm^3

• Hematocrit > 27%

• Absolute neutrophil count ≥ 1,300/mm^3

Hepatic

• Bilirubin ≤ 2.0 mg/dL

• PT ≤ 2 seconds of upper limit of normal (ULN)

• AST and ALT ≤ 10 times ULN

• No Childs class B or C cirrhosis

• No portal hypertension by history, endoscopy, or radiologic studies

Renal

• Creatinine ≤ 1.5 mg/dL OR

• Creatinine clearance > 60 mL/min

Cardiovascular

• No congestive heart failure

• LVEF ≥ 40%

Pulmonary

• No chronic obstructive pulmonary disease

• FEV_1 ≥ 30% of predicted

• DLCO ≥ 40% of predicted

Immunologic

• No active infection

• No severe allergic reaction to iodine contrast agent that is not controlled by premedication with antihistamines or steroids

• No known hypersensitivity reaction to melphalan or heparin in the presence of a heparin induced thrombocytopenia (HIT) antibody

Other

• Weight > 35 kg

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No documented latex allergy

• No evidence of intracranial abnormalities which would lead to risk for bleeding with anticoagulation (e.g., stroke or active metastasis)

• No evidence of active ulcer disease

PRIOR CONCURRENT THERAPY:

Biologic therapy

• More than 1 month since prior biologic therapy and recovered

Chemotherapy

• See Disease Characteristics

• More than 1 month since prior chemotherapy and recovered

Endocrine therapy

• Premenopausal women (i.e., have had a period within the past 12 months) must be willing to undergo hormonal suppression during study treatment

Radiotherapy

• See Disease Characteristics

• More than 1 month since prior radiotherapy and recovered

Surgery

• No prior Whipple resection

Other

• Prior intrahepatic perfusion (with or without arterial infusion with floxuridine) or peripheral hepatic perfusion allowed provided the patient had a radiographic partial response of 3 months' duration after therapy

• No concurrent immunosuppressive drugs

• No concurrent chronic anticoagulation therapy