Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, Leucovorin, and Avastin
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
PRIMARY:
- To determine the toxicity and tolerability of intra-arterial hepatic oxaliplatin every
three weeks administered in combination with systemic intravenous Fluorouracil,
Leucovorin and bevacizumab to patients with advanced solid tumors metastatic to the
liver.
SECONDARY:
- To document in a descriptive fashion the antitumor efficacy of this combination regimen.
- To evaluate the feasibility and accuracy of an alternate radiographic assessment tool
and compare with available tumor markers and RECIST guidelines.
- To estimate in a descriptive fashion the development of extrahepatic tumor recurrences.