HepciFer Study: Hepcidin Overexpression After Hepatectomy : Does Iron Supplementation Make Sense ?

• Status: Completed
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Hepcifer Trial is designed to assess the value of iv iron administration immediately after liver surgery and consequences of inflammation on iron balance. Fifty patients will be randomized in two treatment groups. Patients will be assigned to receive either iv iron or placebo immediately after liver resection surgery. Biological inflammation parameters, hemoglobin, serum iron and hepcidin levels will be assessed prior to surgery and at day 1, 3, 7, 15 and 30 after surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Geneva
• Treatments: Hepcidins; Iron

Criteria

Inclusion Criteria:

• Scheduled liver surgery,

• Liver resection > 2 segments.

Exclusion Criteria:

• Age below 18yrs,

• Pregnancy,

• Emergent surgery,

• Sepsis,

• Immunosuppressive therapy,

• Renal insufficiency (GFR<30ml/min/m2),

• Hypersensitivity to iron,

• Iron overload.