Hepcidin and Glucose Metabolism

• Status: Unknown status
• Trial end date: 2019-11-30
• Target enrollment: 0
• Participant gender: Female

Summary

Gestational diabetes mellitus (GDM), defined as hyperglycemia with blood glucose values above normal but below those diagnostic of DM, and iron deficiency (ID) with or without anemia (IDA) are common during pregnancy. Both disease patterns are associated with an increased risk of complications during pregnancy and at delivery and may have a variety of negative effects on different aspects of child development. Thus, GDM and ID/IDA during pregnancy should be prevented.

Whether iron supplementation with high oral doses acutely increases hepcidin during pregnancy, and whether this acute iron-induced increase in hepcidin decreases insulin sensitivity, is uncertain.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Swiss Federal Institute of Technology
• Collaborators: University Hospital, Zürich; Women's clinc University Hospital Zurich
• Treatments: Hepcidins

Criteria

Inclusion Criteria:

• week of pregnancy 24-28

• pre-pregnancy BMI <27.5kg/m2

• singleton pregnancy

With either:

• GDM and anemia

• GDM and no anemia

OR:

• No GDM and anemia

• No GDM and no anemia

Exclusion Criteria:

• iron infusion within the past 6 months

• severely anemic Hb<8.0g/dl

• acute or chronic disease

• long-term medication

• smoking