SARS-CoV-2 or COVID-19 is representing the major global burden that implicated more than 10
million infected cases and 500 thousand deaths worldwide. The prevalence of this pandemic
disease is expected to rise every day. The challenge is to control its rapid spread meanwhile
looking for a specific treatment to improve patient outcomes. Hesperidin is a classical
herbal medicine used worldwide for a long time with an excellent safety profile. Hesperidin
is a well-known herbal medication used as an antioxidant and anti-inflammatory agent.
Available shreds of evidence support the promising use of hesperidin in prophylaxis and
treatment of COVID 19. Herein, we discuss the possible prophylactic and treatment mechanisms
of hesperidin based on previous and recent findings. Hesperidin can block coronavirus from
entering host cells through ACE2 receptors which can prevent the infection. Anti-viral
activity of hesperidin might constitute a treatment option for COVID-19 through improving
host cellular immunity against infection and its good anti-inflammatory activity may help in
controlling cytokine storm. Hesperidin mixture with diosmin co-administrated with heparin
protect against venous thromboembolism which may prevent disease progression. Based on that,
hesperidin might be used as a meaningful prophylactic agent and a promising adjuvant
treatment option against SARS-CoV-2 infection.