High Dose Amoxicillin Versus Tetracycline as Second-line Treatment of Resistant Helicobacter Pylori Infection

• Status: Completed
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

No trial has examined the the efficacy of high dose amoxicillin based quadruple therapy as second-line treatment for Helicobacter pylori infection. The study aims to compare the effectiveness and safety of 14-day high dose amoxicillin-based quadruple regiment with classical quadruple regiment for rescue eradication of Helicobacter pylori.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Jiao Tong University School of Medicine
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bismuth; Citric Acid; Dexlansoprazole; Lansoprazole; Metronidazole; Potassium Citrate; Proton Pump Inhibitors; Tetracycline

Criteria

Inclusion Criteria:

• all patients had failed H.pylori therapies including clarithromycin, metronidazole and/or amoxicillin (if not allergic) before

• indication of rescue H pylori eradication treatment

• Ability and willingness to participate in the study and to sign and give informed consent

Exclusion Criteria:

• patients less than 18 years old

• previous gastric surgery

• pregnancy or lactation

• major systemic diseases,

• administration of antibiotics, bismuth, antisecretory drugs in the preceding 8 weeks

• allergy to any one of the medication used in the quadruple regimens.