High Dose Bupropion for Smoking Cessation

• Status: Not yet recruiting
• Trial end date: 2023-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to investigate the benefit of administering Bupropion XL (BUP-XL) to heavy smokers who also experience psychiatric symptoms.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Southern California
• Collaborators: University of California, Los Angeles; University of California, San Diego
• Treatments: Bupropion

Criteria

Inclusion Criteria:

• smokes >= 10 cigarettes per day for >= 2 years

• has breath CO ppm >= 10 ppm on intake

• Age 21 - 65

Exclusion Criteria:

• Past year moderate- severe DSM-5 non-tobacco substance use disorder (4+ symptoms)

• Possible drug contraindications (Panic, bipolar, bulimia, anorexia, insomnia, suicidal ideation, alcohol withdrawal, seizures, severe hypertension, renal/hepatic impairment, angle closure glaucoma)

• current use of other cessation medication

• current use of e-cigarettes or other tobacco products > 2X/week

• history of bupropion use

• current anti-psychotic, anxiolytic, antidepressant, or psychostimulant medication use

• currently or plan to be pregnant or breastfeeding