High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention
Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
Participant gender:
Summary
To determine the efficacy of high dose folic acid supplementation for prevention of
preeclampsia in women with at least one risk factor: pre-existing hypertension, pre-pregnancy
diabetes (type 1 or 2), twin pregnancy, preeclampsia in a previous pregnancy, or body mass
index ≥35. It was hypothesized that high dose (4.0 mg per day) supplementation starting in
early pregnancy and continued throughout the entire pregnancy will lower the incidence of
preeclampsia in pregnant women at high risk of developing preeclampsia.