High-Dose Methotrexate and Leucovorin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy, such as methotrexate, work in different ways to stop tumor cells from dividing so they stop growing or die. Leucovorin may decrease side effects caused by high-dose methotrexate.

PURPOSE: This phase II trial is studying how well giving high-dose methotrexate together with leucovorin works in treating patients with newly diagnosed glioblastoma multiforme.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eastern Cooperative Oncology Group
• Collaborator: National Cancer Institute (NCI)
• Treatments: Calcium; Leucovorin; Levoleucovorin; Methotrexate

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed glioblastoma multiforme (GBM)

• Supratentorial grade IV disease

• Measurable and contrast-enhancing disease ≥ 1 cm by CT scan or MRI

• No radiographic evidence of ascites or pleural effusion

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• ECOG 0-2

Life expectancy

• Not specified

Hematopoietic

• Absolute neutrophil count ≥ 1,500/mm^3

• Platelet count ≥ 100,000/mm^3

Hepatic

• SGOT ≤ 4.0 times upper limit of normal

• Bilirubin ≤ 2.0 mg/dL

Renal

• Creatinine ≤ 2.0 mg/dL

• Creatinine clearance ≥ 50 mL/min

Cardiovascular

• No uncontrolled hypertension

• No unstable angina

• No symptomatic congestive heart failure

• No uncontrolled cardiac arrhythmia

• No myocardial infarction within the past 6 months

Other

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• Able to achieve hydration

• No diabetes insipidus

• No known hypersensitivity to methotrexate or leucovorin calcium

• No concurrent serious infection or medical illness that would preclude study participation

• No other malignancy within the past 2 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

Biologic therapy

• No prior immunotherapy for GBM

• No prior administration of any of the following biologic agents for GBM:

• Immunotoxins

• Immunoconjugates

• Antisense therapy

• Peptide receptor antagonists

• Interferons

• Interleukins

• Tumor-infiltrating lymphocytes

• Lymphokine-activated killer cells

• Gene therapy

• No concurrent prophylactic growth factors (e.g., filgrastim [G-CSF] or sargramostim [GM-CSF])

Chemotherapy

• No prior chemotherapy for GBM

• No other concurrent chemotherapy

Endocrine therapy

• Prior glucocorticoid therapy allowed

• No prior hormonal therapy for GBM

• Patients must be maintained on a stable corticosteroid regimen for at least 1 week

Radiotherapy

• No prior cranial irradiation

• No prior radiotherapy for GBM

Surgery

• Recovered from prior surgery

Other

• At least 1 week since prior treatment with any of the following:

• Salicylates

• Non-steroidal anti-inflammatory drugs

• Sulfonamide medications

• Vitamin C

• No other concurrent investigational agents