Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over
the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent
re-bleeding. Intravenous PPI is recommended as a standard treatment.In the past, there were
many trials showing the efficacy of high-dose oral PPI after endoscopic hemostasis but most
were industrial sponsor which assessing an expensive PPI. Moreover, the number of patients in
those studies were insufficient to confirm a non-inferiority outcome in term of rebleeding by
using oral PPI. This study will evaluate a high-dose, local-made PPI (omeprazole) in peptic
ulcer treatment after successful endoscopic hemostasis compared to standard IV PPI continuous
drip.