High Dose PPI Triple Therapy Versus Sequential Therapy for Helicobacter Pylori Eradication

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the efficacy between 1-day high dose PPI-based triple therapy vs. 10-day sequential therapy for Helicobacter pylori eradication in functional dyspepsia patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Collaborator: Takeda Pharmaceuticals International, Inc.
• Treatments: Amoxicillin; Clarithromycin; Lansoprazole

Criteria

Inclusion Criteria:

• Functional dyspepsia patients (Rome III) with rapid urease test positive

• Age ≥ 18 years old

• No history of HP eradication

Exclusion Criteria:

• Recent use of PPI, H2RA, NSAID, Antibiotics within 2 weeks

• Currently use of anticoagulants or ketoconazole

• C/I for gastric biopsy

• History of gastric surgery

• Comorbidity: ESRD, advanced cirrhosis, AIDS, stroke (bed ridden)

• Pregnancy or lactation

• Allergy to studied drugs