High Dose Vitamin C in the Critically Ill Patient

• Status: Terminated
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effectiveness of high doses of Vitamin C in critically ill patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rutgers, The State University of New Jersey
• Treatments: Ascorbic Acid; Vitamins

Criteria

Inclusion Criteria:

• Activation of the Mass Transfusion Protocol following surgery or trauma.

• Diagnosis of septic shock. Septic shock will be defined as sepsis induced hypotension (i.e. systolic blood pressure <90mmHg or drop of systolic blood pressure >40mmHg in the presence of infection) that does not respond to a 2 liter fluid bolus.

Exclusion Criteria:

• Age less than 18 years.

• Pregnant women.

• Creatinine of greater than 2.2 g/dl at time of enrollment, history of chronic kidney or end stage renal disease, rise in creatinine > 1 g/dl within 24 hours prior to enrollment.

• Brain death diagnosed within 4 hours of presentation to the trauma bay or intensive care unit

• Patients with history of hemolytic blood disease, e.g. glucose-6-phosphate dehydrogenase deficiency, Sickle Cell Disease and Thalassemia.

• Patients in isolated cardiogenic shock.

• History of liver cirrhosis

• Transplant patients (liver, kidney, heart)