High Dose Vitamin D Replacement in Patients Undergoing Hematopoietic Stem Cell Transplantation

• Status: Recruiting
• Trial end date: 0000-00-00
• Target enrollment: 160
• Participant gender: Both

Summary

The purpose of this study is to test the efficacy and safety of high dose vitamin D therapy among HSCT patients in a tiered, step-wise manner (step one/two) in order to define treatment doses capable of providing vitamin D sufficiency.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Hospital Medical Center, Cincinnati
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins
• Last Updated: 2016-11-16

Criteria

Inclusion Criteria:

• Step 1: Patients who are preparing for HSCT, 25OHD level (<50 ng/mL), and no prior history of HSCT.

• Step 2: Patients who are preparing for HSCT 25OHD level (<50 ng/mL).

Exclusion Criteria (both Step 1 and Step 2):

• Patients with history of pathologic fractures,

• uncorrected hypocalcemia or hypophosphatemia,

• known history of nephrocalcinosis or nephrolithiasis,

• current granulomatous disease,

• those currently in ICU.