High Protein Formula on Enteral Feeding in Clinical Improvement and Malnutrition at Intensive Care Unit Patients
Status:
Completed
Trial end date:
2018-07-07
Target enrollment:
Participant gender:
Summary
Effectiveness of Early Enteral Feeding With High Protein Polymeric Formula Versus Oligomeric
Formula Versus 5% Dextrose Solution in Clinical Improvement and Malnutrition on Intensive
Care Unit Patients
Background :
Critically ill patients are physiologically unstable, often have complex hypermetabolic
responses to trauma. These patients are facing a high risk of death, multi-organ failure, and
prolonged ventilator use. Nutrition is one of therapy for critical illness, however, patients
often experience malnutrition caused by disease severity, delays in feeding, and
miscalculation of calorie needs, therefore, appropriate management of enteral feeding formula
should be done in preventing malnutrition and improve clinical outcome during intensive
treatment.
Objective:
This study aims to evaluate clinical improvement and malnutrition in critically ill
participants under two different early enteral feeding formulas versus parenteral feeding
Methodology :
A three-arm randomized trial is performed (parenteral (5% Dextrose), and enteral high-protein
polymeric formula, and oligomeric formula.) at the Intensive Care Unit in Wahidin
Sudirohusodo Hospital, Makassar, Indonesia. The enteral feedings are given through a
nasogastric tube within 24-48 hours after intensive care unit (ICU) admission as well as the
parenteral group. A meticulous record of the calories and protein of intake is maintained for
3 days follow up including clinical parameters. The changes between pre and post-intervention
of clinical parameters and nutrition scoring are assessed as the outcome of the intervention
Hypothesis :
Enteral feeding with High Protein Formula provides a better clinical outcome and less
malnutrition event in comparison to 5% Dextrose and Oligomeric Formula