Overview

High Versus Low Dose Nitroglycerin in Acute Pulmonary Edema

Status:
Enrolling by invitation

Trial end date:
2024-07-01

Target enrollment:
0

Participant gender:
All

Summary

The goal of this randomized controlled trial is evaluate the out come of: - Low dose (< 100 mic/min )versus - High dose (> 100 mic/min) of nitroglycerin in management of patients with acute pulmonary edema presented to Emergency Department of Alexandria University Hospitals. The main questions it aims to answer is: - Time of resolution of high blood pressure, hypoxia, tacchypnea - Need for invasive mechanical ventilation, ICU admission

Phase:

Phase 2/Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Alexandria University

Treatments:

Nitroglycerin

Criteria

Inclusion Criteria:

- All adult patients (> 18 years) presented with sympathetic crashing acute pulmonary
edema.

Exclusion Criteria:

1 - Patients indicated for emergency endotracheal intubation. 2-Patients with history of
nitroglycerin allergy. 3-Preload dependent patients as patients with aortic stenosis.
4-Drug interaction with nitroglycerin as sildenafil, ergots. 5-Patients indicated for
emergency percutaneous intervention.