High Volume Injection or Autologous Conditioned Plasma (ACP) in Chronic Achilles Tendinopathy

• Status: Completed
• Trial end date: 2014-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of the study is to examine patients with chronic Achilles Tendinopathy (AT) and to compare the effect of high volume injection (HVI) or autologous conditioned plasma (ACP) in combination with eccentric training to placebo treatment (sham treatment combined with eccentric exercises).

Healthy males with AT will be randomly assigned to either 1) HVI (50 mls;10 mls 0.5% bupivacaine hydrochloride and 20 mg of Depomedrol followed by 40 mls saline), 2) ACP (~ 4 mls) or 3) Placebo (Plc) treatment. All subjects will perform a 12-wk eccentric training program and examinations will be done at baseline (before treatment) with follow-ups after 6 weeks, 12 weeks and again after 24 weeks prior to baseline to see any possible changes and differences between groups (HVI, ACP and Plc)

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bispebjerg Hospital
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• Clinically and ultrasound diagnosed unilateral midt-tendinous achilles tendinopathy

• Symptoms > 3 month

• No steroid injections < 6 month

• 60 males with BMI <30 between 18-60 years.

Exclusion Criteria:

• Bilateral achilles tendinopathy

• Insertional tendinopathy

• Steroid injections < 6 month

• Diabetes or cardiovascular disease

• Smoking

• Treatment with fluoroquinolones < 6 month