High-concentration Small-volume Versus Low-concentration Large-volume Iodine Solution for Esophageal Chromoendoscopy

• Status: Recruiting
• Trial end date: 2024-04-30
• Target enrollment: 0
• Participant gender: All

Summary

This clinical trial aims to test the participants' tolerance for different concentration iodine solutions during esophageal chromoendoscopy. The main question it aims to answer is:

Under the same iodine dosage, do the participants have the same tolerance for 1% and 5% iodine solutions? Participants will be asked to score based on pain and discomfort and describe symptoms and corresponding location at 5 minutes (only for unanesthetized participants) and 30 minutes after chromoendoscopy.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Xijing Hospital of Digestive Diseases
• Collaborators: Air Force 986 Hospital; Ankang Central Hospital; The First Affiliated Hospital of ShiheziI University; Xi'an International Medical Center Hospital; Xianyang Central Hospital (the second people's Hospital of Xianyang City)
• Treatments: Cadexomer iodine; Iodine; Lugol's solution; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Patients undergoing esophageal Lugol's iodine chromoendoscopy.

• Age ≥ 18

Exclusion Criteria:

• Patients allergic to iodine or with hyperthyroidism;

• Patients with esophageal varices, esophageal ulcer or other conditions inadvisable for Lugol chromoendoscopy;

• Patients with severe gastroesophageal reflux disease or reflux symptoms which may interfered with the outcome measures of current study;

• Patients with postoperative esophageal stenosis affecting endoscopic observation;

• Patients who could not cooperate with the observation and data collection including patients with mental disorders, severe neurosis, dysgnosia or communication disorder;

• Patients with advanced-stage tumors;

• Patients after upper gastrointestinal surgery;

• Patients who do not agree to sign informed consent forms or follow the trial requirement.