High-dose Aldosterone Antagonist for Acute Decompensated Heart Failure
Status:
Completed
Trial end date:
2018-04-01
Target enrollment:
Participant gender:
Summary
Primary Aims
1. Evaluate the safety of high-dose spironolactone in combination of patiromer in acute
decompensated heart failure patients.
2. Evaluate the efficacy of high-dose spironolactone in combination of patiromer in causing
volume loss and symptom relief in patients with ADHF treated with high-dose
spironolactone.
Secondary Aims
1: Evaluate the effect of high-dose spironolactone on urinary sodium excretion and renal
function.
Details
Lead Sponsor:
The University of Texas Health Science Center at San Antonio