Histamine as a Molecular Transducer of Adaptation to Exercise

• Status: Recruiting
• Trial end date: 2026-03-31
• Target enrollment: 0
• Participant gender: All

Summary

This study is investigating the role of histamine in generating adaptation to exercise

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oregon
• Treatments: Histamine Antagonists; Histamine H1 Antagonists

Criteria

Inclusion Criteria:

• Age 18 -40

Exclusion Criteria:

• Systolic ≥ 120

• Diastolic ≥ 80

• Body mass index (BMI) ˃ 28 kg/m2

• Prior diagnosis of cardiovascular disease, diabetes, autonomic disorders, or asthma

• Smoking or nicotine use

• Ongoing medical therapy (other than birth control)

• Ongoing use of over-the-counter or prescription antihistamines

• Allergies or hypersensitivities to drugs, local anesthetics, skin disinfectants, adhesives, or latex

• Pregnant, breastfeeding subjects, or planning to become pregnant in the next 12 months

• Mobility restrictions that interfere with physical activity

• High physical activity based on International Physical Activity Questionaire (IPAQ1)

• Non-English speaking