Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles

• Status: Completed
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

Hormonal monitoring impact on overall pregnancy rate in frozen embryo transfer (FET)cycles and hence progesterone supplement adjustments remain debatable in current literature. This prospective randomized study aims to investigate the effect of monitoring and follow-up of serum progesterone, estradiol & luteinizing hormone (LH) levels and progesterone supplement adjustments on pregnancy outcomes for FET in programmed hormonal replacement therapy cycles in comparison with ultrasound only in control group

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Alexandria University
• Treatments: Dydrogesterone; Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Hormones; Polyestradiol phosphate; Progesterone

Criteria

Inclusion Criteria:

1. Age of female patient 42 years or less

2. Normal uterine cavity

3. All embryos are day 5 or day 6 frozen blastocysts

Exclusion Criteria:

1. History of recurrent implantation failure

2. Previously known major thrombophilia factors

3. Non-compliance to given protocol

4. Endometrial thickness < 7mm after 13 days of priming with estradiol valerate

5. pre-existing metabolic diseases (Diabetes Mellitus & Hypertension).