Hormone Therapy and OGX-011 Before Radical Prostatectomy in Treating Patients With Prostate Cancer
Status:
Completed
Trial end date:
2008-09-22
Target enrollment:
Participant gender:
Summary
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as
flutamide and buserelin may stop the adrenal glands from producing androgens. OGX-011 may
help flutamide and buserelin kill more tumor cells by making tumor cells more sensitive to
the drugs. Giving flutamide and buserelin with OGX-011 before surgery may shrink the tumor so
it can be removed during surgery.
PURPOSE: Phase I trial to study the effectiveness of combining hormone therapy with OGX-011
before radical prostatectomy in treating patients who have prostate cancer.