Hospital Insulin Protocol Aims for Glucose Control in Corticosteroid-induced Hyperglycemia

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to determine the best insulin regimen for hospitalized patients who receive high doses of steroids who have high blood glucose.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: HealthPartners Institute
• Collaborators: International Diabetes Center at Park Nicollet; Sanofi
• Treatments: Insulin; Insulin Glargine; Insulin Lispro; Insulin, Globin Zinc; Insulin, Isophane; Isophane insulin, beef; Isophane Insulin, Human

Criteria

Inclusion Criteria:

• Men or women aged ≥18 years who receive steroids in doses greater than physiologic replacement levels of ≥ 10 mg Prednisone or its equivalent of dexamethasone or methylprednisolone.

• Have signed the consent form for the study

• Have a BG > 180 mg/dL any time during the first 24 hour of steroid administration that is above physiological replacement ( ≥ 10 mg Prednisone or equivalent)

• Are scheduled to be in hospital ≥ 2 days.

Exclusion Criteria:

• Unable to read or understand English

• History of psychiatric disability affecting informed consent or compliance with drug intake

• Type 1 diabetes

• Acute or chronic renal failure (creatinine clearance < 30 mL/min estimated by method of Cockcroft and Gault)

• Patients in Hospice Care

• Age <18 years

• Previously enrolled in this study.

• Not appropriate for the steroid protocol in judgment of the principal investigator and/or attending physician.