How Atorvastatin Affects the Gut Flora and Metabolomics?
Status:
Recruiting
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
Recent studies suggest that gut microbiome, the microbial community in the intestine, may
directly and indirectly influence the progression of atherosclerosis. The imbalance of gut
microbiome may directly promote the formation of atherosclerotic plaques by promoting the
inflammatory reaction and oxidative stress affecting vascular endothelial function and
increasing platelet activity. Meanwhile, it can indirectly increase the risk of
atherosclerosis by enhance insulin resistance, reducing the production of bile acids and
raising serum LDL-C and angiotensin levels. As shown in these researches, gut microbiome,
acting as a bridge between metabolism, energy and inflammatory responses, may play an
important role in cardiovascular diseases, and we believe that the interaction between
microbiome and host should be considered in the ASCVD study.
Phase:
N/A
Details
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University