How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine whether one glaucoma eye drop is less likely to cause changes to the surface of the eye (conjunctiva) than another. The two different prostaglandins are Xalatan and Travatan Z.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wills Eye
• Collaborator: Pfizer
• Treatments: Latanoprost; Ophthalmic Solutions; Travoprost

Criteria

Inclusion Criteria:

• Age 21 or older

• Able to understand protocol and agree to 3 visits

• Any type of glaucoma

• Selective laser trabeculoplasty, Argon laser trabeculoplasty, peripheral iridotomy accepted

• Naïve: No prior glaucoma treatment (medical or surgical)

• If patient non-compliant, must be off meds 3 months

• Xalatan: At least one month use

Exclusion Criteria:

• Both Groups: Any history of ocular surface disease

• Dry eye syndrome or prior Restasis use

• Prior ocular surgery other than cataract extractions

• Uveitis or other inflammatory disease of the eye or adnexa

• Systemic medications that might influence ocular inflammation

• Any active inflammation or infection

• Pregnancy or intention to become pregnant

• Naïve: Prior use of topical glaucoma medication unless off for 3 months.

• Use of preserved artificial tear preparations in last 30 days and more than one year history of chronic use

• Xalatan: Prior use of Travatan or Travatan Z