Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis

• Status: Completed
• Trial end date: 2022-09-17
• Target enrollment: 0
• Participant gender: All

Summary

the aim of this clinical trial is to compare the efficacy of hyaluronic acid (HA) used as an adjunctive to scaling and root planing (SRP) and red injectable platelet rich-fibrin (i-PRF) in the non-surgical treatment of stage III periodontitis. The main question it aims to answer is: is there a difference between HA and red i-prf when used as an adjunct to SRP in terms of efficacy?

Participants who are eligible will be assigned to one of the treatment groups:

• Group 1= receives HA+ SRP

• Group 2= receives red i-prf + SRP

• Group 3= receives only SRP

Researchers will compare Groups 1,2 and 3 to see if there's a difference in the periodontal parameters measured.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beirut Arab University
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• clinical periodontal loss and radiographic bone loss of stage III/grades A and B with no history of systemic disease.

• at least four periodontal sites with a pocket depth of six mm or greater

• radiographic evidence of bone loss extending to the middle third of the root

• clinical attachment loss of five mm or more

Exclusion Criteria:

• uncontrolled systemic conditions (uncontrolled diabetes or uncontrolled hypertension)

• bleeding disorders, or on anticoagulant therapy

• alcohol users

• pregnant or lactating females

• heavy smokers (more than ten cigarettes per day)

• chemo or radio therapy

• antibiotic/anti-inflammatory drugs over the last three months before treatment.