Hyaluronic Acid for Residual Periodontal Pockets Adjunctive Treatment
Status:
Completed
Trial end date:
2018-11-01
Target enrollment:
Participant gender:
Summary
Objective: To evaluate the adjunctive effect of hyaluronic acid (HA) gel in the treatment of
residual periodontal pockets over a 12-month period.
Materials and Methods: Periodontal patients enrolled in maintenance and presenting at least
one periodontal pocket 5-9 mm of depth in the anterior area were recruited from six
university-based centers. Each patient was randomly assigned to control treatment with
professional mechanical plaque removal (PMPR) and local placebo application or test treatment
with the adjunctive use of HA to PMPR. Clinical parameters [i.e. probing depth (PD), bleeding
on probing (BoP), plaque score, recession (REC), and clinical attachment loss (CAL)] and
microbiological samples for the investigation of the total bacterial count (TBC) and presence
of specific bacterial strains (Porphyromonas gingivalis, Treponema denticola, Tannerella
forsythia, Fusobacterium nucleatum) were taken at baseline and every 3 months, until study
termination. PD was determined as the primary outcome variable.
Phase:
N/A
Details
Lead Sponsor:
University of Roma La Sapienza
Collaborators:
Jagiellonian University Medical University of Sofia Plovdiv Medical University University of Bern University of Rijeka University of Zagreb