Hyaluronic Acid for Residual Periodontal Pockets Adjunctive Treatment

• Status: Completed
• Trial end date: 2018-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Objective: To evaluate the adjunctive effect of hyaluronic acid (HA) gel in the treatment of residual periodontal pockets over a 12-month period.

Materials and Methods: Periodontal patients enrolled in maintenance and presenting at least one periodontal pocket 5-9 mm of depth in the anterior area were recruited from six university-based centers. Each patient was randomly assigned to control treatment with professional mechanical plaque removal (PMPR) and local placebo application or test treatment with the adjunctive use of HA to PMPR. Clinical parameters [i.e. probing depth (PD), bleeding on probing (BoP), plaque score, recession (REC), and clinical attachment loss (CAL)] and microbiological samples for the investigation of the total bacterial count (TBC) and presence of specific bacterial strains (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum) were taken at baseline and every 3 months, until study termination. PD was determined as the primary outcome variable.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Roma La Sapienza
• Collaborators: Jagiellonian University; Medical University of Sofia; Plovdiv Medical University; University of Bern; University of Rijeka; University of Zagreb
• Treatments: Hyaluronic Acid; Lidocaine

Criteria

Inclusion Criteria:

• at least 18 years of age

• systemically healthy,

• smoking less than 10 cigarettes/day

• having been treated for periodontitis but with at least one single residual pocket of 5-9mm of depth located in the anterior area (incisors and canines)

• full-mouth bleeding score (FMBS)

• full-mouth plaque score (FMPS) less than 20%

• showing a good compliance to oral hygiene instructions

Exclusion Criteria:

• were pregnancy/lactation

• use of antibiotics in the last 3 months for a period of two weeks or more

• use of drugs causing gingival hyperplasia

• use of corticosteroids or anti-inflammatory drugs for a period of two weeks or more

• presence of diseases knowing to influence the wound healing/tissue response

• thyroid or pituitary gland malfunction or abnormal hormonal levels

• hyaluronic acid contraindications

• subjects under anticoagulant treatment

• use of systematic antibiotics for endocarditis prophylaxis

• radiation therapy in head and neck area

• use of bisphosphonate drugs prescribed for patients with osteoarthritis

• tooth mobility.