Hyaluronidase in Intra-articular Steroid Injection Treating the Adhesive Capsulitis for Shoulder

• Status: Completed
• Trial end date: 2019-07-16
• Target enrollment: 0
• Participant gender: All

Summary

Adhesive capsulitis (AC) is painful and disabling condition that is associated with a gradual loss of shoulder motion. Intra-articular steroid injection is a common treatment in the initial painful stage of AC, and its use in combination with hyaluronidase may offer increased therapeutic efficacy owing to synergistic effects. We determined the therapeutic efficiency of the co-administration of hyaluronidase in early AC by evaluating symptomatic, anthropometric, and imaging changes.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Veterans Health Service Medical Center, Seoul, Korea
• Treatments: Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• Normal findings on simple x-rays of the shoulder but limitations in passive range of motion on physical examination

• Increased intra-sheath fluid (ISF) sufficient to encircle the long head of the biceps tendon within the upper portion of the bicipital groove of the humerus.

Exclusion Criteria:

• Ultrasonographic diagnosis of other concomitant fundamental abnormalities causing shoulder pain such as rotator cuff tear, bicipital tendon rupture, calcific tendinopathy, and subacromial-subdeltoid bursitis

• A history of shoulder injury

• A history of more than 1 year of conservative treatment for chronic shoulder pain

• Corticosteroid or hyaluronidase injections within the prior 6 months

• Hemiplegic shoulder

• Self-reported history consistent with scapula fracture or disarticulation

• Ipsilaterally cervical herniated intervertebral disc or brachial plexus injury

• Diabetes mellitus refractory to insulin therapy or glycated hemoglobin greater than 6.5

• Refusal to participate in this study