Hydrogen Peroxide and Nitrite Reduction in Exhaled Breath Condensate of COPD Patients

• Status: Completed
• Trial end date: 2011-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to investigate the effect of inhaled apocynin on ROS (reactive oxygen species) and NOS (reactive nitrogen species) synthesis in 13 COPD patients. Effects of nebulized apocynin (0.5 mg/ml, 6 ml) were assessed in exhaled breath condensate (EBC) after 30, 60 and 120 minutes.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Lodz; Medical Universtity of Lodz
• Collaborator: Ministry of Science and Higher Education, Poland
• Treatments: Acetovanillone; Hydrogen Peroxide

Criteria

Inclusion Criteria:

• patients suffering from bronchial COPD (II and III stage)

• patients free of any medication few days before research

• patients had not suffered from any infectious diseases including upper respiratory tract infections for at least 3 months prior to the study

Exclusion Criteria:

• Patients suffering from GOLD I stage

• patients taking medications few days before the study

• infectious diseases that had occurred 3 months or less before the study