Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
Opioids are commonly used to treat migraine in North American Emergency Departments. We are
comparing efficacy and adverse events of hydromorphone, an opioid, to that of
prochlorperazine, a dopamine antagonist with known efficacy in migraine. Prochlorperazine
will be combined with diphenhydramine to prevent adverse events.