Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia

• Status: Completed
• Trial end date: 2021-01-20
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study is evaluating the strength of combination therapy of hydroxy urea, omega 3, nigella sativa and honey on antioxidant-oxidant status (OXIDATIVE STRESS) in response to reactive oxygen species production (LIPID PEROXIDATION) and their effect on iron intoxication (IRON CHELATION) in pediatric major thalassemia.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beni-Suef University
• Collaborators: Beni-Suef Health insurance hospital; Benisuef university hospital; College of Pharmacy,Department of Pharmacy Practice,University of Arizona; Department of clinical pharmacy, faculty of pharmacy, Beni-suef univeristy; Maternity and Children Hospital, Makkah; University of Arizona
• Treatments: Antioxidants; Deferoxamine; Hydroxyurea; Iron

Criteria

Inclusion Criteria:

1. Any case with full manifestation of β-THALASSEMIA major disease

2. #Aged from 7-15 years old

3. # accompanied with ineffective erythropoiesis

4. # with low hemoglobin level

5. # with iron overload

Exclusion Criteria:

1. The presence of any other chronic illness.

2. Patient age>15 years old or < 7 years old.

3. The presence of concomitant myocardial infarction, stroke, acute chest syndrome.

4. The patient suffers from any other type of anemia.