Hydroxychloroquine Treatment of Dry Eyes in Patients With Primary Sjögren's Syndrome
Status:
Completed
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
Primary Sjögren syndrome is one of the most prevalent autoimmune diseases that present with
dry eye and dry mouth. But there is no proven effective treatment for Sjögren syndrome
patient. The relation between toll-like receptor (TLR) and the pathogenesis of Sjögren
syndrome has been reported. Hydroxychloroquine is TLR7 and TLR9 antagonist. A few studies
have been reported the effectiveness of Hydroxychloroquine for Sjögren syndrome but no
randomized controlled study has been done. So the investigators evaluate the effectiveness
and safeness of Hydroxychloroquine for primary Sjögren syndrome by randomized controlled
study (Hydroxychloroquine 300 mg once daily p.o. group (N = 30) versus placebo group (N =
30).