Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether hydroxychloroquine (HCQ) reduces insulin
resistance in non-diabetic subjects with rheumatoid arthritis (RA). The investigators will
conduct a double-blind randomized crossover trial in subjects with RA to test the hypothesis
that HCQ improves insulin sensitivity. The investigators will also use data from the trial to
identify determinants of insulin resistance in RA. The investigators hypothesize that RA will
be associated with an increased risk of insulin resistance and that independent risk factors
for increased insulin resistance in RA include higher BMI, elevated acute phase reactants,
greater fat to muscle ratio, and less physical activity.
Phase:
Phase 3
Details
Lead Sponsor:
Brigham and Women's Hospital
Collaborator:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)