Hydroxychloroquine vs Nitazoxanide in Patients With COVID-19
Status:
Terminated
Trial end date:
2020-12-30
Target enrollment:
Participant gender:
Summary
Coronaviruses (CoV) are positive-sense single-stranded RNA viruses that infect a wide range
of hosts producing diseases ranging from the common cold to serious / fatal events.
Nitazoxanide (NTZx) is a derivative of 5-nitrothiazole, synthesized in 1974 by Rosignol -
Cavier. NTZx has powerful antiviral effects through the phosphorylation of protein kinase
activated by double-stranded RNA, which leads to an increase in phosphorylated factor
2-alpha, an intracellular protein with antiviral effects. The purpose of this study is to
contrast the beneficial effect of NTZx vs NTZx plus hydroxychloroquine in patients
Coronavirus Disease (COVID-19) as well as against other treatments.